IV Ketamine Therapy in Coral Springs, FL
A rapid-acting medical treatment for severe treatment-resistant depression, anxiety, PTSD, OCD, bipolar depression, and chronic pain conditions. Individual results vary.
Looking for all depression treatment options? See Depression Treatment in Coral Springs.
How IV ketamine works
IV ketamine therapy operates on glutamate pathways in the brain to stimulate synaptogenesis—growing new neural connections that may restore mood regulation and central pain processing. It is not FDA-approved for depression; it is used off-label for depression that has not responded enough to first-line care such as therapy and antidepressants. Individual results vary.
Explore Conditions Treated with IV Ketamine
Calms hyperactive fear networks and brings rapid emotional relief.
An option for treatment-resistant depression, within a full treatment plan.
Acts on central pain sensitization and NMDA pain pathways.
Targeted nerve pain relief for complex regional pain syndrome.
May reduce widespread muscle aches, fibro fog, and sleep disruption.
Interrupts status migrainosus and may reduce attack frequency.
Calms diabetic neuropathy and post-herpetic burning nerve pain.
Given under strict psychiatric guidance for bipolar depressive states.
May lessen hypervigilance, nightmares, and trauma reactivity.
Interrupts cortico-striatal obsessive loops and compulsive urges.
Provides crisis stabilization within hours of infusion.
What Happens During Your Ketamine Infusion?
Comprehensive Evaluation
Our board-certified medical team reviews your full history to confirm candidacy and customize your dose.
Monitored Infusion
You relax in a private suite while a low sub-anesthetic dose is slowly infused over 45 to 60 minutes.
Post-Infusion Recovery
Short relaxation period after the infusion. Mild dissociation resolves quickly, leaving you refreshed.
What research shows for IV ketamine in depression
In controlled studies of off-label IV ketamine for depression, patients reported rapid reductions in depressive symptoms within hours to days of a single infusion, including in treatment-resistant depression. Effects were not always durable after one dose, and repeated infusions were studied for maintenance. A consultation reviews your full history — including which antidepressants you have already tried — before any off-label option is considered. Individual results may vary.
First-line depression care remains psychotherapy (CBT, DBT) and medication management (SSRIs, SNRIs, and other antidepressants). IV ketamine is an advanced option, not a replacement for that foundation.
IV ketamine vs SPRAVATO®: the key difference
SPRAVATO® (esketamine) is a nasal-spray form of ketamine that is FDA-approved for adults with treatment-resistant depression and for depressive symptoms in adults with major depressive disorder who have acute suicidal thoughts or behavior. It is given in the clinic under a REMS (Risk Evaluation and Mitigation Strategy) program with at least two hours of observation after each dose, and patients must not drive until the next day after a restful sleep.
IV ketamine is not FDA-approved for depression and is used off-label. Both act on the glutamate system, but they are different products with different regulatory status, dosing, and monitoring. Learn more on our SPRAVATO® page and our ketamine vs SPRAVATO® comparison.
IV ketamine vs SPRAVATO® vs SAINT® for depression
| Option | FDA status for depression | How given | Sessions | Observation & driving | Insurance |
|---|---|---|---|---|---|
| Therapy & antidepressants | First-line; many antidepressants FDA-approved | Talk therapy + daily medication | Weekly; ongoing | None; drive normally | May be covered; varies by plan |
| Standard TMS | FDA-cleared for MDD | Magnetic stimulation, in clinic | ~36 visits over ~6 weeks | None; drive normally | May be covered; varies by plan |
| SPRAVATO® (esketamine) | FDA-approved for TRD and for depressive symptoms in MDD with acute suicidal thoughts/behavior | Nasal spray, in clinic | Induction phase, then maintenance | ≥2-hour observation; no driving until next day after restful sleep | May be covered; varies by plan |
| IV ketamine | Off-label for depression | IV infusion, in clinic | Series of infusions | Monitored; no driving same day | Often not covered |
| SAINT® Neuromodulation System | FDA-cleared for MDD after inadequate antidepressant response; adults 22+ | fMRI-guided accelerated TMS, in clinic | 5 consecutive days | Monitored; driving guidance per clinician | May be covered; varies by plan |
Ketamine-assisted psychotherapy (KAP)
Ketamine-assisted psychotherapy (KAP) pairs off-label IV ketamine sessions with guided therapy work in the window when ketamine may make thinking more flexible. Therapy before, during, and after the medicine session helps you integrate what comes up. KAP is not a separate medication approval; the ketamine remains off-label for depression. Learn more on our ketamine-assisted psychotherapy page.
Frequently asked questions
Cited research
- Zarate CA Jr, Brutsche NE, Ibrahim L, et al. “Replication of ketamine’s antidepressant efficacy in bipolar depression: a randomized controlled add-on trial.” Biol Psychiatry 2012;71(10):939–946. doi.org/10.1016/j.biopsych.2011.12.006
- Murrough JW, Iosifescu DV, Chang LC, et al. “Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial.” Am J Psychiatry 2013;170(10):1134–1142. doi.org/10.1176/appi.ajp.2013.13030392
- Glue P, Neehoff L, Medlicott NJ, et al. “Safety and efficacy of maintenance ketamine treatment in treatment-resistant depression.” J Psychopharmacol 2020;34(6):655–663. doi.org/10.1177/0269881120914810
- U.S. Food and Drug Administration. “FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor’s office or clinic.” FDA news release, March 5, 2019. fda.gov
- Cole EJ, Phillips AL, Bentzley BS, et al. “Stanford Neuromodulation Therapy (SANT) for treatment-resistant depression.” Am J Psychiatry 2022;179(2):132–141. doi.org/10.1176/appi.ajp.2021.20101499
When to get help now
This page is for education and is not medical advice. Treatment options depend on a full evaluation. If you are thinking about suicide or are in crisis, call or text 988 (Suicide & Crisis Lifeline), or call 911 or go to the nearest emergency room.
- IV ketamine: dissociation, increased blood pressure, nausea.
- SPRAVATO®: dissociation, sedation, increased blood pressure.
- TMS: headache, scalp discomfort, small risk of seizure.
- SAINT®: seizure risk, headache, scalp discomfort.
Talk to a specialist about your options, free
A free consultation reviews your depression history and matches you to the right starting point — whether that is therapy, medication, SPRAVATO®, or an advanced option such as off-label ketamine, TMS, or SAINT®. We verify your insurance benefits for free. Individual results vary.
SAINT® is a registered trademark of Stanford University, exclusively licensed to Magnus Medical, Inc. Neuro Wellness TMS Centers of America is not affiliated with Stanford University. SPRAVATO® is a registered trademark of Johnson & Johnson.
Explore Related Treatments & Resources
Depression Treatment in Coral Springs
Our full-service depression care hub: TMS, SAINT®, SPRAVATO®, therapy, and medication.
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Ketamine for Depression
Ketamine for PTSD
Ketamine for OCD
Ketamine for Bipolar Disorder
Ketamine for Chronic Pain
Ketamine for CRPS
Ketamine for Fibromyalgia
Ketamine for Migraines
Ketamine for Neuropathic Pain
Ketamine for Suicidal Ideation
SAINT® Accelerated TMS
FDA-cleared, 5-day accelerated TMS protocol
Standard TMS Therapy
Non-invasive magnetic stimulation for depression
SPRAVATO® (Esketamine)
FDA-approved nasal spray for TRD
Prism for PTSD & Depression
EEG neurofeedback for PTSD symptoms
Proliv®Rx At-Home TMS
At-home neuromodulation device
Ampa One System
Single-day accelerated TMS protocol
IV Ketamine Infusions
Rapid-acting IV ketamine therapy
Ketamine-Assisted Psychotherapy
KAP combines ketamine with therapy
PrTMS Therapy
Personalized repetitive TMS
Psychotherapy & Counseling
CBT, DBT, EMDR, and more
Medication Management
Psychiatric medication oversight
Ampa One Day Accelerated Protocol
Single-day accelerated protocol
TMS for Depression
FDA-cleared TMS for treatment-resistant depression
TMS for Anxiety
Non-drug neuromodulation for anxiety
TMS for PTSD
Targeted stimulation for trauma circuits
TMS for OCD
SmartFocus® 3D targeting for OCD
Traveling for Treatment
What the week looks like, hotels, what to bring
Verify a SAINT Provider
How to confirm a center truly offers SAINT
SAINT vs. Standard TMS
Key differences in targeting, schedule, and duration
I've Already Tried TMS
Prior TMS doesn't disqualify you
How Insurance Works
Benefits verification, authorization, appeals
Am I a Candidate?
Screening factors — not disqualifiers
Compare Treatments
Side-by-side matrix of all treatments
For Families & Caregivers
Supporting someone through treatment
Cost & Insurance
Financing options and insurance information
Let's find your path forward — together
Reaching out is the hardest part, and you've already started. Tell us a little about yourself and our compassionate care team will reach out within one business day to answer your questions, verify your insurance, and help you take the next step — at no cost and no obligation.
Two pathways to care: self-pay offers the fastest access (most patients start within days, with appointments available seven days a week), or we accept Blue Cross Blue Shield in select states and the BCBS Federal Employee Program in select states. We'll help you find the right path for your situation.
- Warm, judgment-free consultation — no pressure, just answers
- Flexible scheduling: Zoom or in-person, including weekends
- Same-day or next-day appointments often available