A new path to depression relief beyond medication
Proliv®Rx is a prescription-based, FDA-cleared neuromodulation therapy for adults whose depression hasn’t responded sufficiently to medication. It is designed for use at home, under physician guidance.
NeuroRouter At-Home Headset
Gentle, targeted nerve pathways stimulation under medical supervision.
Why Choose Proliv®Rx?
If you’re struggling with depression that hasn’t improved with medication alone, Proliv®Rx offers a new path forward.
A proven next-step therapy
For those who haven’t adequately improved with medication alone
Treatment at home
No clinics or waiting rooms - use it at the privacy of your home
Advanced brain neuromodulation
Targets key brain pathways linked to depression
Clinically demonstrated
Meaningful improvement in depression symptoms
Adjunctive therapy
Enhances the effects of your current antidepressant treatment
Fits into daily life
Use while resting or watching TV
Physician-guided care
Prescribed and monitored by your doctor
Safe and drug-free
Non-invasive and well-tolerated
How Proliv®Rx Works
Your brain is a network of more than 80 billion neurons that communicate using tiny electrical signals. These signals share information across different regions of the brain.
In depression, communication between regions becomes disrupted, affecting mood and emotional well-being.
Proliv®Rx is designed to improve communication and connectivity across the brain. Using advanced neuromodulation, it harnesses the brain’s natural capacity to change, helping build healthier neural connections.
With its wearable headset called the NeuroRouter, Proliv®Rx delivers gentle electrical signals through electrodes (NeuroPorts) placed on the forehead and the back of the head.
Much like how a router directs signals in a network, the NeuroRouter helps guide these signals precisely and non-invasively along natural nerve pathways to key regions involved in depression.
With consistent use, Proliv®Rx helps restore balance in your brain, so you can feel better again.
NeuroRouter Technology
Gentle electrical signals target trigeminal and occipital nerve pathways non-invasively.
What Does It Feel Like?
Proliv®Rx therapy is designed to be comfortable and pain-free. Most people describe the sensation as a gentle tingling on the scalp.
During treatment, you remain fully awake, comfortable, and able to resume normal daily activities immediately afterward.
What Your Treatment Journey Looks Like
A structured, physician-guided process designed to fit seamlessly into your life.
Talk with your physician
Your physician will review your symptoms and treatment history to determine whether Proliv®Rx is appropriate for you. If prescribed, they will guide you through what to expect and address any questions you may have.
Proven Results & Safety Profile
Does It Work?
In the Proliv®Rx clinical study, 87% of patients with prior inadequate response to antidepressant medications improved by one or more depression severity levels.
- 56% reached mild or no depression
- 31.7% achieved full remission
Results after 16 weeks of therapy program completion.
Is It Safe?
- FDA-Cleared: Met FDA requirements for safety and effectiveness through the 510(k) clearance pathway.
- Non-Invasive: Generally mild to moderate, transient side effects (e.g., mild scalp tingling).
- Data-Driven Progress: Reports are shared with your prescribing physician to support ongoing progress monitoring and care adjustments.
What Leading Psychiatrists Are Saying
"This effective and highly accessible therapy with a favorable safety profile, addresses a significant unmet need in this underserved patient population and expands how we can deliver care."
Mark George, MD
Professor of Psychiatry, Radiology and Neurosciences and Director of the Brain Stimulation Division at the Medical University of South Carolina (MUSC)
"Proliv®Rx offers an accessible and effective solution for patients whose depression is unresponsive to medications, many of whom have endured years of persistent symptoms. This therapy has the potential to become an essential tool in the mental health treatment landscape."
Linda Carpenter, MD
Professor of Psychiatry at Brown University and Chief of the Mood Disorder Program at Butler Hospital
"Never before has there been an FDA-cleared treatment option for difficult-to-treat depression that is safe, effective, and can be used privately in the patient's home - expanding access to therapy for this underserved population. Proliv Rx just treats depression - without the hassle."
Owen Scott Muir, MD
Chief Medical Officer, Neurolief. Dual board-certified psychiatrist and leading researcher in neuromodulation for treatment-resistant mood disorders.
Frequently Asked Questions
Who is Proliv®Rx for
Proliv®Rx therapy
Insurance Coverage
Ask Your Physician About Proliv®Rx Today
If you want your physician to know about Proliv®Rx, share our official clinical information brochure with them.
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