SPRAVATO® vs. Ketamine: What's the Difference?
SPRAVATO® and IV ketamine are related treatments, but they are not the same. Understanding the distinction matters when you're considering treatment options.
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Esketamine vs. Ketamine
SPRAVATO® contains esketamine, a specific form of ketamine. While they are chemically related, they are different formulations. SPRAVATO® is FDA-approved as a prescription medication for treatment-resistant depression. IV ketamine is administered as an infusion and is used off-label for depression.
How Each Is Administered
| Feature | SPRAVATO® (Esketamine) | IV Ketamine |
|---|---|---|
| Form | Prescription nasal spray | Intravenous infusion |
| Administration | Self-administered under supervision | Administered by clinical staff via IV |
| Setting | Certified REMS treatment center | Outpatient clinical setting |
| Monitoring | 2 hours observation after each dose | Monitored throughout infusion |
| FDA status for depression | FDA-approved | Used off-label |
| Insurance coverage | Covered by many plans with prior auth | Often not covered for depression |
| Schedule | Twice weekly, tapering | Series of infusions |
Form
Administration
Setting
Monitoring
FDA status for depression
Insurance coverage
Schedule
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Medical Supervision
Both treatments require medical supervision. SPRAVATO® is given at a certified REMS center with a required monitoring period. IV ketamine is administered in a clinical setting with monitoring throughout the infusion. Neither is a take-home treatment.
Insurance Considerations
Because SPRAVATO® is FDA-approved for depression, many insurance plans have an established process for covering it. IV ketamine, used off-label for depression, is often not covered by insurance. We can verify your benefits for whichever treatment you're considering.
Individualized Evaluation
Which treatment may be appropriate depends on your clinical history, current medications, and circumstances. We offer both, and a consultation is where we discuss which makes more sense for your situation.
Frequently Asked Questions
Is SPRAVATO® just nasal ketamine?
Which is more effective, SPRAVATO® or IV ketamine?
Does insurance cover IV ketamine for depression?
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You Don't Have to Figure This Out Alone
Both treatments are available at our center. Speak with our team about which may make more sense for your situation.