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    Treatment-Resistant Depression
    SAINT by Magnus Medical

    TMS for Treatment-Resistant Depression

    If you've tried two or more antidepressants without adequate relief, TMS may be an option. Here's what you need to know.

    What treatment-resistant depression is

    Treatment-resistant depression (TRD) is not a failure on your part. It's a clinical category describing depression that hasn't responded adequately to at least two antidepressants from different classes, taken at adequate doses for a sufficient duration.

    About a third of people with depression don't get adequate relief from oral antidepressants. That's not a small unlucky minority — it's a known limitation of how those medications work, and treatments were developed specifically for this situation.

    How TMS is different

    TMS works through a different mechanism than oral antidepressants. Instead of changing chemical signaling throughout your body, TMS uses focused magnetic pulses to stimulate specific areas of the brain involved in mood regulation — primarily the dorsolateral prefrontal cortex.

    It's FDA-cleared, non-invasive, and performed in an outpatient setting. You sit in a chair, stay awake, and can drive yourself home afterward.

    Treatment options for TRD

    • Standard TMS — sessions 5 days/week for ~6 weeks, FDA-cleared
    • SAINT accelerated TMS — 5-day protocol with fMRI targeting, FDA-cleared
    • SPRAVATO (esketamine) — FDA-approved nasal spray for TRD
    • IV ketamine infusions — off-label but widely used
    • Ketamine-assisted psychotherapy (KAP)
    • Medication management — adjusting or augmenting current medications

    Your next step

    A consultation is the place to sort through which treatment may be right for you. We'll review your history, what you've tried, and what your insurance may cover.

    Call (954) 827-9793 or schedule a consultation.

    Schedule a Free Phone Consultation

    No commitment. We'll review your situation, answer your questions, and help you understand whether SAINT or another treatment is the right fit. One phone call — (954) 827-9793.